Topical delivery of lycopene using microemulsions: enhanced skin penetration and tissue antioxidant activity.

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dc.contributor.authorLopes, Luciana B
dc.contributor.authorVanDeWall, Hillary*
dc.contributor.authorLi, Hsin T*
dc.contributor.authorVenugopal, Vijay*
dc.contributor.authorLi, Hsin K*
dc.contributor.authorNaydin, Stan*
dc.contributor.authorHosmer, Jaclyn M*
dc.contributor.authorLevendusky, Mark C*
dc.contributor.authorZheng, HaiAn
dc.contributor.authorBentley, M Vitória L B
dc.contributor.authorLevin, Robert M
dc.contributor.authorHass, Martha A
dc.contributor.orcidhttps://orcid.org/0000-0002-3981-9860
dc.date.accessioned2023-10-25T13:53:39Z
dc.date.available2023-10-25T13:53:39Z
dc.date.issued2010-03
dc.descriptionClick on the Resource Link to access the article (may not be free).
dc.description.abstractTopical delivery of lycopene is a convenient way to supplement cutaneous levels of antioxidants. In this study, lycopene was incorporated (0.05%, w/w) in two microemulsions containing BRIJ-propylene glycol (2:1, w/w, surfactant blend) but different oil phases: mono/diglycerides of capric and caprylic acids (MG) or triglycerides of the same fatty acids (TG). Microemulsions containing MG and TG were isotropic, fluid, and clear, with internal phase diameters of 27 and 52 nm, respectively. Both MG- or TG-containing microemulsions markedly increased lycopene penetration in the stratum corneum (6- and 3.6-fold, respectively) and in viable layers of porcine ear skin (from undetected to 172.6 +/- 41.1 and 103.1 +/- 7.2 ng/cm(2), respectively) compared to a control solution. To assure that lycopene delivered to the skin was active, the antioxidant activity of skin treated with MG-containing microemulsion was determined by CUPRAC assay, and found to be 10-fold higher than untreated skin. The cytotoxicity of MG-containing microemulsion in cultured fibroblasts was similar to propylene glycol (considered safe) and significantly less than of sodium lauryl sulfate (a moderate-to-severe irritant) at 1-50 microg/mL. These results demonstrate that the MG-containing microemulsion is an efficient and safe system to increase lycopene delivery to the skin and the antioxidant activity in the tissue.
dc.description.urihttps://doi.org/10.1002/jps.21929
dc.identifier.citationLopes LB, VanDeWall H, Li HT, Venugopal V, Li HK, Naydin S, Hosmer J, Levendusky M, Zheng H, Bentley MV, Levin R, Hass MA. Topical delivery of lycopene using microemulsions: enhanced skin penetration and tissue antioxidant activity. J Pharm Sci. 2010 Mar;99(3):1346-57. doi: 10.1002/jps.21929. PMID: 19798758.
dc.identifier.issn0022-3549
dc.identifier.other19798758
dc.identifier.urihttps://hdl.handle.net/20.500.14303/211
dc.language.isoen
dc.publisherAmerican Pharmaceutical Association
dc.relation.ispartofJournal of Pharmaceutical Sciences
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). http://rightsstatements.org/vocab/InC/1.0/
dc.subjectAntioxidants
dc.subjectLycopene
dc.subjectSkin
dc.titleTopical delivery of lycopene using microemulsions: enhanced skin penetration and tissue antioxidant activity.
dc.typeArticle
local.departmentprogramDepartment of Life Sciences
local.departmentprogramDepartment of Pharmaceutical Sciences
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