The role of lipids and lipid metabolites in urinary bladder dysfunction induced by partial outlet obstruction.

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Issue Date
2003-01
Authors
Hass, Martha A
Levin, Robert M
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Abstract
Benign prostate hyperplasia (BPH) frequently progresses to cause partial outlet obstruction of the urinary bladder, resulting in a range of symptoms including urine retention, poor flow, nocturia, and detrusor instability. Over 80% of males 50 to 60 years of age and older have various degrees of bladder outlet obstruction secondary to BPH that results in urinary dysfunction. The urinary dysfunction in men with BPH is related to functional, structural, and biochemical changes that occur in both the smooth muscle and urothelial components of the urinary bladder during urethral obstruction by the enlarged prostate. However, the specific pathophysiology that leads to BPH symptoms remains unknown. The ability to develop rational therapeutic interventions for the treatment of bladder dysfunction associated with BPH requires an understanding of the pathological changes that occur in the underlying cellular mechanisms responsible for maintaining normal bladder function.
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Hass MA, Levin RM. The role of lipids and lipid metabolites in urinary bladder dysfunction induced by partial outlet obstruction. Adv Exp Med Biol. 2003;539(Pt A):217-37. doi: 10.1007/978-1-4419-8889-8_16. PMID: 15088907.
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