Measurement of free fraction, total concentration and protein binding for testosterone, triiodothyronine and thyroxine.
Loading...
Issue Date
10/17/2023
Authors
Klock, Emily*
Kane, Michael P
Musteata, Florin M
Degree
Advisor
Committee Members
Journal Title
Journal ISSN
Volume Title
Abstract
Measuring the total and free concentrations of hormones is useful, but the technology to do this simultaneously is lacking. A new method offers the ability to measure these parameters concurrently for testosterone, thyroxine and triiodothyronine. The free concentrations showed significant correlations with patients' vital statistics. Overall, 67% of correlations for total concentration showed that the new and classical methods had equal accuracy, or that comprehensive ultrafiltration was more accurate. The protein binding term was found to correlate significantly with the patients' luteinizing hormone, prostate-specific antigen and height. Comprehensive ultrafiltration for measuring the total concentration, free concentration and protein binding term uses less sample and is much faster than measuring these parameters with three separate methods.
Citation
Klock E, Kane MP, Musteata FM. Measurement of free fraction, total concentration and protein binding for testosterone, triiodothyronine and thyroxine. Bioanalysis. 2023 Oct 17. doi: 10.4155/bio-2023-0126. Epub ahead of print. PMID: 37847058.
ACPHS Research Commons URI
Description
Click on the Resource Link to access the article (may not be free).
Resource Link
Grants
1R15GM126510/GM/NIGMS NIH HHS/United States