Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Bloodstream Infections.

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Issue Date
2022-02-01
Authors
Lodise, Thomas P
Scheetz, Marc
Carreno, Joseph J
Chambers, Henry
Fowler, Vance
Holland, Thomas L
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Abstract
Among patients with methicillin-resistant bacteremia, vancomycin-associated acute kidney injury increased as a function of the day 2 area under the curve (AUC), even for daily AUCs within the recommended therapeutic range (400-600). Further data are needed to determine if daily AUCs <400 can be maintained without compromising efficacy.
Citation
Lodise TP, Scheetz M, Carreno JJ, Chambers H, Fowler V Jr, Holland TL. Associations Between Vancomycin Exposure and Acute Kidney Injury Within the Recommended Area Under the Curve Therapeutic Exposure Range Among Patients With Methicillin-Resistant Staphylococcus aureus Bloodstream Infections. Open Forum Infect Dis. 2022 Jan 22;9(2):ofab651. doi: 10.1093/ofid/ofab651. PMID: 35079599; PMCID: PMC8783632.
ACPHS Research Commons URI
https://hdl.handle.net/20.500.14303/629
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https://doi.org/10.1093/ofid/ofab651
 http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8783632/
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Lodise, Thomas P. Publications
Carreno, Joseph Publications