Stability of ciprofloxacin injection in peritoneal dialysis solutions.
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Issue Date
2/1/1994
Authors
Kane, Michael P
Bailie, George R
Moon, Dudley G
Siu, Irene*
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Abstract
The stability of ciprofloxacin 25 mg/L in peritoneal dialysis solutions containing 1.5% and 4.25% dextrose after storage at 4 degrees C for two weeks, 25 degrees C for one week, or 37 degrees C for two days was evaluated. Ciprofloxacin 50 mg was added to 18 2-L bags of peritoneal dialysis solutions, nine containing 1.5% dextrose and nine containing 4.25% dextrose. Three bags of each dialysis solution were stored at 4 degrees C for 14 days, 25 degrees C for 7 days, and 37 degrees C for 2 days. Samples were drawn from each bag, and ciprofloxacin concentrations were measured by high-performance liquid chromatography. Stability was defined as less than 10% decrease from initial concentration. In the solution containing 1.5% dextrose, 87.2% of the ciprofloxacin remained after 14 days of storage at 4 degrees C, 93.4% remained after 7 days of storage at 25 degrees C, and 95.2% remained after 2 days of storage at 37 degrees C. In the solution containing 4.25% dextrose, 89.0% of the ciprofloxacin remained after 14 days of storage at 4 degrees C, 93.7% remained after 7 days of storage at 25 degrees C, and 97.8% remained after 2 days of storage at 37 degrees C. In peritoneal dialysis solutions containing 1.5% and 4.25% dextrose, ciprofloxacin was stable for seven days at 25 degrees C and for 48 hours at 37 degrees C. Ciprofloxacin concentrations after two weeks at 4 degrees C were below 90% of initial concentration.
Citation
Kane MP, Bailie GR, Moon DG, Siu I. Stability of ciprofloxacin injection in peritoneal dialysis solutions. Am J Hosp Pharm. 1994 Feb 1;51(3):373-7. PMID: 8160691.
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