Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus.

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2007-10
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Lodise, Thomas P
McKinnon, Peggy S
Levine, Donald P
Rybak, Michael J
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Abstract
This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.
Citation
Lodise TP Jr, McKinnon PS, Levine DP, Rybak MJ. Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2007 Oct;51(10):3731-3. doi: 10.1128/AAC.00101-07. Epub 2007 Jul 30. PMID: 17664322; PMCID: PMC2043293.
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https://hdl.handle.net/20.500.14303/754
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https://doi.org/10.1002/jcph.1281
 http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2043293
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Lodise, Thomas P. Publications