Investigating Transdermal Delivery of Vitamin D3
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Issue Date
2013
Authors
Alsaqr, Ahmed Abdullah '13
Degree
MS in Pharmaceutical Sciences
Advisor
Musteata, Marcel F
Committee Members
Millington, William
Voigt, Jeffrey
Voigt, Jeffrey
Journal Title
Journal ISSN
Volume Title
Abstract
Vitamin D3 (cholecalciferol) is a fat soluble vitamin approved for the treatment of vitamin D deficiency. Transdermal delivery is proposed for this drug to overcome its poor and variable oral bioavailability. In this study, the effect of different penetration enhancers, such as oleic acid, dodecylamine, ethanol, oleic acid in propylene glycol, isopropyl myristate, octyldodecanol, and oleyl alcohol in propylene glycol were evaluated in vitro for delivery of vitamin D3 through polyamide filter, polydimethylsiloxane (PDMS) membrane, and pig skin. A diffusion cell was used to study the transdermal permeability of vitamin D3. The ointment containing oleic acid as chemical penetration enhancers did not significantly enhance the permeability through polyamide filter, polydimethylsiloxane membrane and pig skin compared to control. However, the formulation containing dodecylamine as a penetration enhancer improved the delivery of vitamin D3 for both the filter and the PDMS membranes, but failed to improve it for pig skin. Only dodecylamine significantly enhanced vitamin D3 penetration into the epidermis after the skin was pretreated with 50% ethanol.
Citation
Alsaqr AA. Investigating transdermal delivery of vitamin D3 [thesis]. Ann Arbor (MI): Proquest/UMI; 2013. 83p.
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