A Retrospective Cohort Analysis Shows that Coadministration of Minocycline with Colistin in Critically Ill Patients Is Associated with Reduced Frequency of Acute Renal Failure.

Simple item page
dc.contributor.authorLodise, Thomas P
dc.contributor.authorFan, Weihong
dc.contributor.authorGriffith, David C
dc.contributor.authorDudley, Michael N
dc.contributor.authorSulham, Katherine A
dc.contributor.orcidhttps://orcid.org/0000-0002-4730-0655
dc.date.accessioned2025-02-07T19:35:03Z
dc.date.available2025-02-07T19:35:03Z
dc.date.issued2018-01
dc.description.abstractNonclinical studies have suggested that oxidative damage, caspase-mediated apoptosis, and inducible nitric oxide synthase levels may be involved in the pathogenesis of colistin (CST)-associated acute renal failure. MIN inhibits caspase 1, caspase 3, and inducible nitric oxide synthase, leading to the hypothesis that coadministration of CST with MIN (CST-MIN) may reduce the incidence of acute renal failure as well as produce additive or synergistic antimicrobial effects. A multicenter retrospective cohort study was conducted using the Premier Research database to examine the impact of CST-MIN on acute renal failure. Inclusion criteria were as follows: age of >/=18 years, intensive care unit admission at CST initiation, primary International Classification of Diseases 9 (ICD-9) diagnosis of pneumonia or sepsis, nondialysis at hospital admission, and discharge between January 2010 and December 2015. ICD-9 code 584.XX or ICD-10 code N17 was used to define acute renal failure. Baseline comparisons, 1:8 propensity score matching, and confirmatory logistic regression analyses were conducted. In total, 4,817 patients received CST and met inclusion criteria; 93 received CST-MIN. Unadjusted frequency of acute renal failure was significantly lower in patients receiving CST-MIN than CST (11.8% versus 23.7%, P = 0.007). Similar results were seen in propensity score matching (12.0% versus 22.3%, P = 0.031) and logistic regression analyses (odds ratio of 0.403, P = 0.006). Mortalities and 30-day readmission rates were similar between groups. The acute renal failure rate was not impacted by prevalence of baseline renal disease. CST-MIN in critically ill patients may reduce CST-associated acute renal failure. Further evaluation of this combination in prospective clinical studies is warranted.
dc.description.urihttps://doi.org/10.1128/AAC.01165-17
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc5740356
dc.identifier.citationLodise TP, Fan W, Griffith DC, Dudley MN, Sulham KA. A Retrospective Cohort Analysis Shows that Coadministration of Minocycline with Colistin in Critically Ill Patients Is Associated with Reduced Frequency of Acute Renal Failure. Antimicrob Agents Chemother. 2017 Dec 21;62(1):e01165-17. doi: 10.1128/AAC.01165-17. PMID: 29038261; PMCID: PMC5740356.
dc.identifier.issn0066-4804
dc.identifier.other29038261
dc.identifier.urihttps://hdl.handle.net/20.500.14303/806
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofAntimicrobial Agents and Chemotherapy
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). http://rightsstatements.org/vocab/InC/1.0/
dc.subjectAcute Kidney Injury/etiology/mortality/prevention & control
dc.subjectAdult
dc.subjectAged
dc.subjectCohort Studies
dc.subjectColistin/administration & dosage/therapeutic use
dc.subjectCritical Illness
dc.subjectFemale
dc.subjectIntensive Care Units
dc.subjectLength of Stay/economics
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMinocycline/administration & dosage/therapeutic use
dc.subjectPatient Readmission/statistics & numerical data
dc.subjectProtective Agents/administration & dosage/therapeutic use
dc.subjectRetrospective Studies
dc.subjectTreatment Outcome
dc.titleA Retrospective Cohort Analysis Shows that Coadministration of Minocycline with Colistin in Critically Ill Patients Is Associated with Reduced Frequency of Acute Renal Failure.
dc.typeArticle
local.departmentprogramDepartment of Pharmacy Practice
Files
Collections
Lodise, Thomas P. Publications