Health-related quality of life in colorectal cancer survivors: are there differences between sporadic and hereditary patients?
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Issue Date
2017
Authors
Burton-Chase, Allison M
Parker, Wendy M
Donato, Kirsten M
McCormick, Shannon
Gritz, Ellen R
Amos, Christopher I
Lu, Karen H
Lynch, Patrick M
Rodriguez-Bigas, Miguel A
Nancy You, Y
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Abstract
Purpose: To compare health-related quality of life (HRQoL) in colorectal cancer (CRC) survivors with sporadic CRC to those with hereditary cancer, specifically Lynch syndrome (LS).
Methods: Participants completed a mailed self-administered questionnaire that assessed, among other things, demographics, clinical characteristics, and health-related quality of life. Using a case-case design, CRC survivors with LS or sporadic cancer were matched on age, sex, race/ethnicity, cancer stage, geography, and time since diagnosis. Participants were recruited from patient registries at The University of Texas MD Anderson Cancer Center (MD Anderson) (n = 33 LS; n = 75 sporadic) and through social media (n = 42 LS). The final sample included 71 LS and 74 sporadic CRC survivors.
Results: For LS patients, the mean FACT-C HRQoL score was 84.8 (11.9) [Median = 86.0; Interquartile Range-17] compared to sporadic patients mean score of 85.8 (16.7) [Median = 92.0; Interquartile Range-21], which indicates high quality of life for both groups. LS patients and sporadic CRC patients had similar HRQoL mean scores across 7 different HRQoL metrics, with no significant differences between groups. Exploratory regression analyses indicate some differences in known predictors of HRQoL by group despite no bivariate differences.
Conclusions: HRQoL is an important component of survivorship in CRC patients. Given the clinical distinctions between LS and sporadic patients, we expected to find significant differences between these patients. However, the patients' experiences/quality of life does not appear to illustrate such a clear dissimilarity within CRC survivors. Given the limited data in this area, larger studies, ideally with data obtained from multiple sites, is needed to better investigate the alignment between clinical determination and patient experience as well as to explore the relationship between HRQOL, treatment regimens, and health outcomes.
Citation
Burton-Chase AM, Parker WM, Donato KM, McCormick S, Gritz ER, Amos CI, Lu KH, Lynch PM, Rodriguez-Bigas MA, Nancy You Y, Peterson SK. Health-related quality of life in colorectal cancer survivors: are there differences between sporadic and hereditary patients? J Patient Rep Outcomes. 2017;2(1):21. doi: 10.1186/s41687-018-0047-4. Epub 2018 May 1. PMID: 29757305; PMCID: PMC5934923.
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P30 CA016672/CA/NCI NIH HHS/United States