Retrospective, propensity score--matched study examining the relationship between frailty and Clostridioides difficile infection in a national cohort of US veterans

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dc.contributor.authorReveles, Kelly R.
dc.contributor.authorStrey, Kelsey A.
dc.contributor.authorAlbuquerque, Esther L
dc.contributor.authorJacota, Damaris
dc.contributor.authorJones, Xavier
dc.contributor.authorCarreno, Joseph J.
dc.contributor.orcidhttps://orcid.org/0000-0001-9272-6973
dc.date.accessioned2024-12-05T17:42:36Z
dc.date.available2024-12-05T17:42:36Z
dc.date.issued2024-12
dc.descriptionClick on the Resource Link to access the article (may not be free).
dc.description.abstractBackground: Frailty is often more predictive of disease and mortality compared with chronological age. This study determined the impact of frailty on Clostridioides difficile infection (CDI) risk and outcomes in a national veteran population.
dc.description.abstractMethods: This was a retrospective cohort study of CDI and control veteran inpatients and outpatients from fiscal year 2003 to 2018. Baseline frailty was presented as the Veterans Affairs (VA) Frailty Index. Propensity score--matched analyses were conducted to compare CDI risk, CDI health outcomes, and 1-year new-onset frailty-associated conditions.
dc.description.abstractResults: A total of 11,451 CDI and 11,451 matched control patients were included. Baseline frailty conditions were more common among CDI patients, especially involuntary weight loss (6.0% vs 3.4%, P < .001) and anemia (24.6% vs 18.7%, P < .001). VA Frailty Index was significantly higher for CDI patients (0.13 vs 0.11, P = .019). Frail CDI patients were more likely to experience 30-day mortality (11.3% vs 1.1%, P < .001) and 60-day CDI recurrence (20.4% vs 16.3%, P < .001) compared with non-/prefrail CDI patients. At 1year, CDI patients were significantly more likely to be categorized as frail (19.6% vs 17.0%, P < .001).
dc.description.urihttps://doi.org/10.1016/j.ajic.2024.08.020
dc.identifier.citationReveles KR, Strey KA, Albuquerque EL, Jacota D, Jones X, Carreno JJ. Retrospective, propensity score--matched study examining the relationship between frailty and Clostridioides difficile infection in a national cohort of US veterans. Am J Infect Control. 2024 Dec;52(12):1412-1418. doi: 10.1016/j.ajic.2024.08.020. Epub 2024 Aug 26. PMID: 39197729.
dc.identifier.issn0196-6553
dc.identifier.other39197729
dc.identifier.urihttps://hdl.handle.net/20.500.14303/633
dc.language.isoen
dc.publisherMosby
dc.relation.ispartofAmerican Journal of Infection Control
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). http://rightsstatements.org/vocab/InC/1.0/
dc.subjectClostridium Infections / epidemiology
dc.subjectClostridium Infections / mortality
dc.subjectFrailty / epidemiology
dc.subjectPropensity Score
dc.subjectVeterans / statistics & numerical data
dc.titleRetrospective, propensity score--matched study examining the relationship between frailty and Clostridioides difficile infection in a national cohort of US veterans
dc.typeArticle
local.departmentprogramDepartment of Pharmacy Practice
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