Economic Impact of Recurrent Clostridioides difficile Infection in the USA: A Systematic Literature Review and Cost Synthesis.

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dc.contributor.authorReveles, Kelly R
dc.contributor.authorYang, Min
dc.contributor.authorGarcia-Horton, Viviana
dc.contributor.authorEdwards, Marie Louise
dc.contributor.authorGuo, Amy
dc.contributor.authorLodise, Thomas
dc.contributor.authorBochan, Markian
dc.contributor.authorTillotson, Glenn
dc.contributor.authorDubberke, Erik R
dc.contributor.orcidhttps://orcid.org/0000-0002-4730-0655
dc.date.accessioned2025-02-07T19:35:07Z
dc.date.available2025-02-07T19:35:07Z
dc.date.issued2023-07
dc.descriptionClick on the Resource Link to access the article (may not be free).
dc.description.abstractIntroduction: Up to 35% of patients with a first episode of Clostridioides difficile infection (CDI) develop recurrent CDI (rCDI), and of those, up to 65% experience multiple recurrences. A systematic literature review (SLR) was conducted to review and summarize the economic impact of rCDI in the United States of America. Methods: English-language publications reporting real-world healthcare resource utilization (HRU) and/or direct medical costs associated with rCDI in the USA were searched in MEDLINE, MEDLINE In-Process, Embase, and the Cochrane Library databases over the past 10 years (2012-2022), as well as in selected scientific conferences that publish research on rCDI and its economic burden over the past 3 years (2019-2022). HRU and costs identified through the SLR were synthesized to estimate annual rCDI-attributable direct medical costs to inform the economic impact of rCDI from a US third-party payer's perspective. Results: A total of 661 publications were retrieved, and 31 of them met all selection criteria. Substantial variability was found across these publications in terms of data source, patient population, sample size, definition of rCDI, follow-up period, outcomes reported, analytic approach, and methods to adjudicate rCDI-attributable costs. Only one study reported rCDI-attributable costs over 12 months. Synthesizing across the relevant publications using a component-based cost approach, the per-patient per-year rCDI-attributable direct medical cost was estimated to range from $67,837 to $82,268. Conclusions: While real-world studies on economic impact of rCDI in the USA suggested a high-cost burden, inconsistency in methodologies and results reporting warranted a component-based cost synthesis approach to estimate the annual medical cost burden of rCDI. Utilizing available literature, we estimated the average annual rCDI-attributable medical costs to allow for consistent economic assessments of rCDI and identify the budget impact on US payers.
dc.description.urihttps://doi.org/10.1007/s12325-023-02498-x
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc10272265/
dc.identifier.citationReveles KR, Yang M, Garcia-Horton V, Edwards ML, Guo A, Lodise T, Bochan M, Tillotson G, Dubberke ER. Economic Impact of Recurrent Clostridioides difficile Infection in the USA: A Systematic Literature Review and Cost Synthesis. Adv Ther. 2023 Jul;40(7):3104-3134. doi: 10.1007/s12325-023-02498-x. Epub 2023 May 21. PMID: 37210680; PMCID: PMC10272265.
dc.identifier.issn0741-238X
dc.identifier.other37210680
dc.identifier.urihttps://hdl.handle.net/20.500.14303/836
dc.language.isoen
dc.publisherHealth Communications Inc.
dc.relation.ispartofAdvances in Therapy
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dc.subjectCost estimation
dc.subjectHealthcare resource utilization
dc.subjectMedical costs
dc.subjectRecurrent Clostridioides difficile infection
dc.subjectSystematic literature review
dc.titleEconomic Impact of Recurrent Clostridioides difficile Infection in the USA: A Systematic Literature Review and Cost Synthesis.
dc.typeArticle
local.departmentprogramDepartment of Pharmacy Practice
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