Central Nervous System Controls Pulmonary Inflammation during Septic Shock

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dc.contributor.advisorFeleder, Carlos
dc.contributor.authorPeng, Jianya '14
dc.contributor.committeememberJohnson, Arnold
dc.contributor.committeememberMalik, Meenakshi
dc.date.accessioned2023-04-20T17:48:07Z
dc.date.available2023-04-20T17:48:07Z
dc.date.issued2014
dc.descriptionClick on the Resource Link to find this item in the ACPHS Library catalog.
dc.description.abstractTo investigate the participation of the central endocannabinoid in mediating acute lung inflammation (ALI) during septic shock, the hypothesis was tested that the brain endocannabinoid type 1 (CB-1) receptor antagonist rimonabant prevents lipopolysaccharide (LPS) induced lung inflammation. Rats were pretreated with rimonabant (500ng) or vehicle by an intracerebroventricular (ICV) injection 5 minutes prior to intravenous (IV) injection of either LPS (5 mg/kg) or saline, followed by additional ICV injections at 1.5 and 3 hours post-LPS in the 4 hour treatment groups. Lungs were removed at 30 minutes or 4 hours after IV injection. The isolated-perfused lung was assessed for hemodynamics. Lung homogenates were assessed for Toll-like receptor 4 (TLR4) signaling cascade markers and α7 nicotinic acetylcholine receptor (α7nAChR) activity.
dc.description.abstractConclusions: The data indicate that antagonism of the central CB-1 receptors inhibits the initiation and progression of the lung inflammatory response to LPS.
dc.description.degreeMS in Pharmaceutical Sciences
dc.description.urihttps://acphs.on.worldcat.org/oclc/990026195
dc.format.extent74 pages
dc.identifier.citationPeng J. Central nervous system controls pulmonary inflammation during septic shock [thesis]. Ann Arbor (MI): Proquest/UMI; 2014. 84 p.
dc.identifier.urihttps://hdl.handle.net/20.500.14303/85
dc.languageen_US
dc.publisherProQuest LLC
dc.relation.ispartofAlbany College of Pharmacy and Health Sciences Theses
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dc.subjectAcute Lung Inflammation
dc.subjectEndocannabinoid
dc.subjectSeptic Shock
dc.subjectTLR4 signaling
dc.titleCentral Nervous System Controls Pulmonary Inflammation during Septic Shock
dc.typeThesis
local.departmentprogramDepartment of Pharmaceutical Sciences
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