Lactate Dehydrogenase as a Biomarker for Early Renal Damage in Patients with Sickle Cell Disease
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Issue Date
2013
Authors
Alzahri, Mohammad '13
Degree
MS in Health Outcomes Research
Advisor
Mousa, Shaker
Committee Members
Racz, Michael
Polimeni, John
Almomen, Abdulkareem
Polimeni, John
Almomen, Abdulkareem
Journal Title
Journal ISSN
Volume Title
Abstract
Introduction:
Among many complications of sickle cell disease, renal failure is the main contributor to early mortality. It is present in up to 21% of patients with sickle cell disease. Although screening for microalbuminuria and protienuria is the current acceptable practice to detect and follow renal damage in patients with sickle cell disease, there is a crucial need for other, more sensitive biomarkers. This becomes especially true knowing that those biomarkers start to appear only after more than 60% of the kidney function is lost. The primary purpose of this study is to determine whether Lactate dehydrogenase correlates with other, direct and indirect, biomarkers of renal insufficiency in patients with sickle cell disease, and, therefore, could be used as a biomarker for early renal damage in patients with sickle cell disease.
Materials and Methods:
Fifty-five patients with an established diagnosis of sickle cell disease were recruited to enroll in the study. Blood samples were taken and 24-hour urine collection samples were collected. Using Statcrunch, a data analysis tool available on the WEB, we studied the correlation between LDH and other biomarkers of kidney function, as well as the distribution and relationship between the variables.
Results:
Regression analysis showed significant negative correlation between serum LDH and creatinine clearance, R (correlation coefficient) = - 0.44, P = 0.0008. This correlation was more significant at younger age.
Conclusions:
This study shows that in sickle cell patients, LDH correlates with creatinine clearance and, therefore, LDH could serve as a biomarker to predict renal insufficiency in those patients.
Among many complications of sickle cell disease, renal failure is the main contributor to early mortality. It is present in up to 21% of patients with sickle cell disease. Although screening for microalbuminuria and protienuria is the current acceptable practice to detect and follow renal damage in patients with sickle cell disease, there is a crucial need for other, more sensitive biomarkers. This becomes especially true knowing that those biomarkers start to appear only after more than 60% of the kidney function is lost. The primary purpose of this study is to determine whether Lactate dehydrogenase correlates with other, direct and indirect, biomarkers of renal insufficiency in patients with sickle cell disease, and, therefore, could be used as a biomarker for early renal damage in patients with sickle cell disease.
Materials and Methods:
Fifty-five patients with an established diagnosis of sickle cell disease were recruited to enroll in the study. Blood samples were taken and 24-hour urine collection samples were collected. Using Statcrunch, a data analysis tool available on the WEB, we studied the correlation between LDH and other biomarkers of kidney function, as well as the distribution and relationship between the variables.
Results:
Regression analysis showed significant negative correlation between serum LDH and creatinine clearance, R (correlation coefficient) = - 0.44, P = 0.0008. This correlation was more significant at younger age.
Conclusions:
This study shows that in sickle cell patients, LDH correlates with creatinine clearance and, therefore, LDH could serve as a biomarker to predict renal insufficiency in those patients.
Citation
Alzahri, Mohammad Shami. "Lactate Dehydrogenase As a Biomarker for Early Renal Damage in Patients with Sickle Cell Disease." Albany College of Pharmacy and Health Sciences, New York, Proquest/UMI, 2013.
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