Prescribing of Proton Pump Inhibitors for Prevention of Upper Gastrointestinal Bleeding in US Outpatient Visits.
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Issue Date
2024-09
Authors
Kurlander, Jacob E
Mafi, John N
Racz, Michael J
Barnes, Geoffrey D
Saini, Sameer D
Meek, Patrick D
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Abstract
Antisecretory medications, primarily proton pump inhibitors (PPIs), have proven effective in reducing upper gastrointestinal toxicities, including upper gastrointestinal bleeding (UGIB), associated with nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin, which are among the most commonly used medications in the United States. Accordingly, professional guidance recommends PPIs for patients at high risk for UGIB. However, little is known about trends in use of antisecretory medications for gastrointestinal prophylaxis ("gastroprotection"). Herein, we examined contemporary use and prescribing of antisecretory medications in visits by patients at high risk for UGIB, relative to visits by patients diagnosed with acid-related disorders.
Citation
Kurlander JE, Mafi JN, Racz MJ, Barnes GD, Saini SD, Meek PD; Gastrointestinal Bleeding Working Group. Prescribing of Proton Pump Inhibitors for Prevention of Upper Gastrointestinal Bleeding in US Outpatient Visits. Clin Gastroenterol Hepatol. 2024 Sep;22(9):1937-1941.e4. doi: 10.1016/j.cgh.2024.01.047. Epub 2024 Feb 15. PMID: 38367740.
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K76 AG064392/AG/NIA NIH HHS/United States