Monitoring Ceftazidime-Avibactam and Aztreonam Concentrations in the Treatment of a Bloodstream Infection Caused by a Multidrug-Resistant Enterobacter sp. Carrying Both Klebsiella pneumoniae Carbapenemase-4 and New Delhi Metallo-beta-Lactamase-1.

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dc.contributor.authorYasmin, Mohamad
dc.contributor.authorFouts, Derrick E
dc.contributor.authorJacobs, Michael R
dc.contributor.authorHaydar, Hanan
dc.contributor.authorMarshall, Steven H
dc.contributor.authorWhite, Richard
dc.contributor.authorD'Souza, Roshan
dc.contributor.authorLodise, Thomas P
dc.contributor.authorRhoads, Daniel D
dc.contributor.authorHujer, Andrea M
dc.contributor.authorRojas, Laura J
dc.contributor.authorHoyen, Claudia
dc.contributor.authorPerez, Federico
dc.contributor.authorEdwards, Amy
dc.contributor.authorBonomo, Robert A
dc.contributor.orcidhttps://orcid.org/0000-0002-4730-0655
dc.date.accessioned2025-02-07T19:34:55Z
dc.date.available2025-02-07T19:34:55Z
dc.date.issued8/14/2020
dc.description.abstractIn an infection with an Enterobacter sp. isolate producing Klebsiella pneumoniae Carbapenemase-4 and New Delhi Metallo-beta-Lactamase-1 in the United States, recognition of the molecular basis of carbapenem resistance allowed for successful treatment by combining ceftazidime-avibactam and aztreonam. Antimicrobial synergy testing and therapeutic drug monitoring assessed treatment adequacy.
dc.description.grantGrant Funded
dc.description.sponsorshipU19 AI110819/AI/NIAID NIH HHS/United States
dc.description.sponsorshipR01 AI100560/AI/NIAID NIH HHS/United States
dc.description.sponsorshipR01 AI063517/AI/NIAID NIH HHS/United States
dc.description.sponsorshipR01 AI072219/AI/NIAID NIH HHS/United States
dc.description.urihttps://doi.org/10.1093/cid/ciz1155
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc7428388
dc.identifier.citationYasmin M, Fouts DE, Jacobs MR, Haydar H, Marshall SH, White R, D'Souza R, Lodise TP, Rhoads DD, Hujer AM, Rojas LJ, Hoyen C, Perez F, Edwards A, Bonomo RA. Monitoring Ceftazidime-Avibactam and Aztreonam Concentrations in the Treatment of a Bloodstream Infection Caused by a Multidrug-Resistant Enterobacter sp. Carrying Both Klebsiella pneumoniae Carbapenemase-4 and New Delhi Metallo-β-Lactamase-1. Clin Infect Dis. 2020 Aug 14;71(4):1095-1098. doi: 10.1093/cid/ciz1155. PMID: 31802119; PMCID: PMC7428388.
dc.identifier.issn1058-4838
dc.identifier.other31802119
dc.identifier.urihttps://hdl.handle.net/20.500.14303/715
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartofClinical Infectious Diseases
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). http://rightsstatements.org/vocab/InC/1.0/
dc.subjectAnti-Bacterial Agents/pharmacology/therapeutic use
dc.subjectAzabicyclo Compounds/therapeutic use
dc.subjectAztreonam/therapeutic use
dc.subjectBacteremia/drug therapy
dc.subjectBacterial Proteins
dc.subjectCeftazidime/therapeutic use
dc.subjectDrug Combinations
dc.subjectEnterobacter
dc.subjectKlebsiella Infections/drug therapy
dc.subjectKlebsiella pneumoniae/genetics
dc.subjectMicrobial Sensitivity Tests
dc.subjectUnited States
dc.subjectbeta-Lactamases/genetics
dc.titleMonitoring Ceftazidime-Avibactam and Aztreonam Concentrations in the Treatment of a Bloodstream Infection Caused by a Multidrug-Resistant Enterobacter sp. Carrying Both Klebsiella pneumoniae Carbapenemase-4 and New Delhi Metallo-beta-Lactamase-1.
dc.typeArticle
local.departmentprogramDepartment of Pharmacy Practice
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