Pharmacokinetics and pharmacodynamics: optimal antimicrobial therapy in the intensive care unit.

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dc.contributor.authorLodise, Thomas P
dc.contributor.authorDrusano, George L
dc.contributor.orcidhttps://orcid.org/0000-0002-4730-0655
dc.date.accessioned2025-02-07T19:34:59Z
dc.date.available2025-02-07T19:34:59Z
dc.date.issued2011-01
dc.descriptionClick on the Resource Link to access the article (may not be free).
dc.description.abstractThis article reviews the principles of antimicrobial pharmacokinetics and pharmacodynamics in the context of the ICU for the most commonly used antibiotics. For therapy to truly be efficacious, the regimen must be effective against the organism, but not harmful to the patient. We review how optimization of chemotherapy requires a careful balancing of efficacy against toxicity when selecting dose and dose schedules. In addition, we discuss the importance of considering concentrations at the site of infection and how dose optimization can help suppress resistance emergence and preserve our antimicrobial armamentarium for the future. Finally, we examine combination chemotherapy and strategies for optimizing the administration of multiple agents.
dc.description.urihttps://doi.org/10.1016/j.ccc.20https://doi.org/10.11.003
dc.identifier.citationLodise TP, Drusano GL. Pharmacokinetics and pharmacodynamics: optimal antimicrobial therapy in the intensive care unit. Crit Care Clin. 2011 Jan;27(1):1-18. doi: 10.1016/j.ccc.2010.11.003. PMID: 21144983.
dc.identifier.issn0749-0704
dc.identifier.other21144983
dc.identifier.urihttps://hdl.handle.net/20.500.14303/768
dc.language.isoen
dc.publisherElsevier Health Sciences Division
dc.relation.ispartofCritical Care Clinics
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). http://rightsstatements.org/vocab/InC/1.0/
dc.subjectAnti-Infective Agents/administration & dosage/adverse effects/pharmacokinetics
dc.subjectClinical Trials as Topic/methods/standards
dc.subjectDrug Administration Schedule
dc.subjectDrug Interactions
dc.subjectDrug Resistance, Microbial
dc.subjectDrug Therapy, Combination
dc.subjectIntensive Care Units
dc.subjectMonte Carlo Method
dc.titlePharmacokinetics and pharmacodynamics: optimal antimicrobial therapy in the intensive care unit.
dc.typeArticle
local.departmentprogramDepartment of Pharmacy Practice
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