Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review.

Simple item page
dc.contributor.authorDoernberg, Sarah B
dc.contributor.authorArias, Cesar A
dc.contributor.authorAltman, Deena R
dc.contributor.authorBabiker, Ahmed
dc.contributor.authorBoucher, Helen W
dc.contributor.authorCreech, C Buddy
dc.contributor.authorCosgrove, Sara E
dc.contributor.authorEvans, Scott R
dc.contributor.authorFowler, Vance G
dc.contributor.authorFritz, Stephanie A
dc.contributor.authorHamasaki, Toshimitsu
dc.contributor.authorKelly, Brendan J
dc.contributor.authorLeal, Sixto M
dc.contributor.authorLiu, Catherine
dc.contributor.authorLodise, Thomas P
dc.contributor.authorMiller, Loren G
dc.contributor.authorMunita, Jose M
dc.contributor.authorMurray, Barbara E
dc.contributor.authorPettigrew, Melinda M
dc.contributor.authorRuffin, Felicia
dc.contributor.authorScheetz, Marc H
dc.contributor.authorShopsin, Bo
dc.contributor.authorTran, Truc T
dc.contributor.authorTurner, Nicholas A
dc.contributor.authorWilliams, Derek J
dc.contributor.authorZaharoff, Smitha
dc.contributor.authorHolland, Thomas L
dc.contributor.orcidhttps://orcid.org/0000-0002-4730-0655
dc.date.accessioned2025-02-07T19:34:57Z
dc.date.available2025-02-07T19:34:57Z
dc.date.issued10/16/2023
dc.descriptionClick on the Resource Link to access the article (may not be free).
dc.description.abstractThe Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its core areas of emphasis. The ARLG Gram-positive Committee has focused on studies responding to 3 main identified research priorities: (1) investigation of strategies or therapies for infections predominantly caused by gram-positive bacteria, (2) evaluation of the efficacy of novel agents for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, and (3) optimization of dosing and duration of antimicrobial agents for gram-positive infections. Herein, we summarize ARLG accomplishments in gram-positive bacterial infection research, including studies aiming to (1) inform optimal vancomycin dosing, (2) determine the role of dalbavancin in MRSA bloodstream infection, (3) characterize enterococcal bloodstream infections, (4) demonstrate the benefits of short-course therapy for pediatric community-acquired pneumonia, (5) develop quality of life measures for use in clinical trials, and (6) advance understanding of the microbiome. Future studies will incorporate innovative methodologies with a focus on interventional clinical trials that have the potential to change clinical practice for difficult-to-treat infections, such as MRSA bloodstream infections.
dc.description.grantGrant Funded
dc.description.sponsorshipUM1AI104681)/NH/NIH HHS/United States
dc.description.urihttps://doi.org/10.1093/cid/ciad565
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc10578051
dc.identifier.citationDoernberg SB, Arias CA, Altman DR, Babiker A, Boucher HW, Creech CB, Cosgrove SE, Evans SR, Fowler VG, Fritz SA, Hamasaki T, Kelly BJ, Leal SM, Liu C, Lodise TP, Miller LG, Munita JM, Murray BE, Pettigrew MM, Ruffin F, Scheetz MH, Shopsin B, Tran TT, Turner NA, Williams DJ, Zaharoff S, Holland TL; Antibacterial Resistance Leadership Group. Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review. Clin Infect Dis. 2023 Oct 16;77(Supplement_4):S295-S304. doi: 10.1093/cid/ciad565. PMID: 37843115; PMCID: PMC10578051.
dc.identifier.issn1058-4838
dc.identifier.other37843115
dc.identifier.urihttps://hdl.handle.net/20.500.14303/737
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartofClinical Infectious Diseases
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). http://rightsstatements.org/vocab/InC/1.0/
dc.subjectantibacterial agents
dc.subjectantibacterial resistance
dc.subjectgram-positive bacterial infections
dc.subjectmethicillin-resistant Staphylococcus aureus
dc.subjectvancomycin-resistant enterococci
dc.titlePriorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review.
dc.typeArticle
local.departmentprogramDepartment of Pharmacy Practice
Files
Collections
Lodise, Thomas P. Publications