HIV-Associated Neurocognitive Disorder: A Look into Cellular and Molecular Pathology.

Simple item page
dc.contributor.authorThompson, Landon John-Patrick*
dc.contributor.authorGenovese, Jessica*
dc.contributor.authorHong, Zhenzi*
dc.contributor.authorSingh, Meera Vir
dc.contributor.authorSingh, Vir Bahadur
dc.contributor.orcidhttps://orcid.org/0000-0002-8022-5167
dc.date.accessioned2024-08-05T12:33:14Z
dc.date.available2024-08-05T12:33:14Z
dc.date.issued2024-04-25
dc.descriptionClick on the Resource Link to access the article (may not be free).
dc.description.abstractDespite combined antiretroviral therapy (cART) limiting HIV replication to undetectable levels in the blood, people living with HIV continue to experience HIV-associated neurocognitive disorder (HAND). HAND is associated with neurocognitive impairment, including motor impairment, and memory loss. HIV has been detected in the brain within 8 days of estimated exposure and the mechanisms for this early entry are being actively studied. Once having entered into the central nervous system (CNS), HIV degrades the blood-brain barrier through the production of its gp120 and Tat proteins. These proteins are directly toxic to endothelial cells and neurons, and propagate inflammatory cytokines by the activation of immune cells and dysregulation of tight junction proteins. The BBB breakdown is associated with the progression of neurocognitive disease. One of the main hurdles for treatment for HAND is the latent pool of cells, which are insensitive to cART and prolong inflammation by harboring the provirus in long-lived cells that can reactivate, causing damage. Multiple strategies are being studied to combat the latent pool and HAND; however, clinically, these approaches have been insufficient and require further revisions. The goal of this paper is to aggregate the known mechanisms and challenges associated with HAND.
dc.description.grantGrant Funded
dc.description.sponsorshipAI165295/National Institute of Allergy and Infectious Diseases
dc.description.sponsorshipHL160229/National Heart Lung and Blood Institute
dc.description.sponsorshipAI162076/National Institute of Allergy and Infectious Diseases
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc11083163/
dc.description.urihttps://doi.org/10.3390/ijms25094697
dc.identifier.citationThompson LJ, Genovese J, Hong Z, Singh MV, Singh VB. HIV-Associated Neurocognitive Disorder: A Look into Cellular and Molecular Pathology. Int J Mol Sci. 2024 Apr 25;25(9):4697. doi: 10.3390/ijms25094697. PMID: 38731913; PMCID: PMC11083163.
dc.identifier.issn1422-0067
dc.identifier.other38731913
dc.identifier.urihttps://hdl.handle.net/20.500.14303/603
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rightsThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). http://rightsstatements.org/vocab/InC/1.0/
dc.subjectHAND
dc.subjectHIV
dc.subjectlatency
dc.subjectmicroglia
dc.subjectneuroinflammation
dc.subjectplatelet
dc.titleHIV-Associated Neurocognitive Disorder: A Look into Cellular and Molecular Pathology.
dc.typeArticle
local.departmentprogramDepartment of Life Sciences
Files
Collections
Singh, Vir Publications
Student - Faculty Publications